The core mission of our lab is to understand the inheritance and evolution of genome instability, especially in the context of cancer biology. By combining real-time evolutionary experiment and in silico genomic analysis, we approach this research theme via the following research lines.
- Constructing the genotype-phenotype map for genome instability via the lens of pangenome graph.
- Dissecting the inheritance and evolutionary mechanisms of genome instability via experimental evolution with cell models (mainly the budding and fission yeasts).
- Elucidating the evolutionary patterns and clinical implications of genome instability during cancer and cancer-associated virus evolution via the genomic analysis of clinical sequencing data.
- Developing novel sequencing technologies that targets genome instability via single-molecular sequencing.
- Building handy bioinformatics applications that quantitatively profile and visualize genome instability via comparative genomics.