[In English]
Our lab aims to study the omics characteristics, evolutionary dynamics, and targeting methodologies of genome instability. Specifically, we approach this goal via the following research lines.
- Illuminating the multi-omics characteristics of genome instability and the associated functional implications.
(Keywords: mutation, recombination, pangenome, structural variants, complex regions, repetitive sequences ) - Elucidating the evolutionary trajectories of genome instability and the underlying regulatory mechanisms.
(Keywords: experimental evolution, aneuploidy, polyploidy, phenotypic adaptivity, population heterogeneity) - Developing novel targeting technologies of genome instability regarding its detection and intervention.
(Keywords: single-molecule sequencing, telomere, subtelomere, cellular senescence, synthetic lethality)
[In Chinese]
我们课题组致力于研究基因组不稳定性的组学表征、演化动态、以及靶向技术。具体来讲，我们从以下三个方面开展研究：
- 阐明基因组不稳定性的多组学表征及功能意义
（关键词：突变、重组、泛基因组、结构变异、复杂区域、重复序列） - 解析基因组不稳定性的演化轨迹及调控机制
（关键词：实验演化、非整倍体、多倍体、表型适应性、群体异质性） - 开发基因组不稳定性的靶向测定及干预新技术
（关键词：单分子测序、端粒、亚端粒、细胞衰老、合成致死）
