Saccharomyces cerevisiae Reference Assembly Panel Database (ScRAPdb)
Saccharomyces cerevisiae Reference Assembly Panel Database (ScRAPdb)
A searchable table of the S. cerevisiae pangenome ORFs defined in Peter et al. (2018) Nature (LINK) is provided below. The listed core/accessory classification and origin assignment are based on the original study. Click on the PanORF ID to find out the detailed presence/absence pattern of the corresponding pangenome ORF in both ScRAPdb and the 1002ScGP strain collections (which were recalculated by ScRAPdb).
| PanORF ID | SGD systematic Name | SGD standard name | Alias | Description | Type | Origin assignment | Mostly likely origin species | NCBI megablast hit |
|---|---|---|---|---|---|---|---|---|
| 7763-YPR145C-A | YPR145C-A | NA | NA | Putative protein of unknown function | Accessory | Ancestral | NA | NA |
| 7764-YPR145W | YPR145W | ASN1 | asparagine synthase (glutamine-hydrolyzing) 1 | Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN1 has a paralog, ASN2, that arose from the whole genome duplication | Accessory | Ancestral | NA | NA |
| 7765-YPR146C | YPR146C | NA | NA | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data | Core | NA | NA | NA |
| 7766-YPR147C | YPR147C | NA | NA | Protein of unknown function; may have a role in lipid metabolism, based on localization to lipid droplets; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS | Accessory | Ancestral | NA | NA |
| 7767-YPR148C | YPR148C | NA | NA | Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern | Accessory | Ancestral | NA | NA |
| 7768-YPR149W | YPR149W | NCE102 | NCE2 | Protein of unknown function; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs); NCE102 has a paralog, FHN1, that arose from the whole genome duplication | Accessory | Ancestral | NA | NA |
| 7769-YPR151C_NumOfGenes_2 | YPR151C | SUE1 | NA | Protein required for degradation of unstable forms of cytochrome c; located in the mitochondria | Accessory | Ancestral | NA | NA |
| 7770-YPR152C | YPR152C | URN1 | NA | Protein of unknown function containing WW and FF domains; overexpression causes accumulation of cells in G1 phase | Accessory | Ancestral | NA | NA |
| 7771-YPR153W | YPR153W | MAY24 | NA | Protein of unknown function | Accessory | Ancestral | NA | NA |
| 7772-YPR154W | YPR154W | PIN3 | LSB2 | Negative regulator of actin nucleation-promoting factor activity; interacts with Las17p, a homolog of human Wiskott-Aldrich Syndrome protein (WASP), via an N-terminal SH3 domain, and along with LSB1 cooperatively inhibits the nucleation of actin filaments; short-lived protein whose levels increase in response to thermal stress; induces the formation of the [PIN+] and [RNQ+] prions when overproduced; PIN3 has a paralog, LSB1, that arose from the whole genome duplication | Accessory | Ancestral | NA | NA |
| 7773-YPR155C | YPR155C | NCA2 | NA | Protein that regulates expression of Fo-F1 ATP synthase subunits; involved in the regulation of mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; functions with Nca3p | Accessory | Ancestral | NA | NA |
| 7774-YPR157W | YPR157W | TDA6 | NA | Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; null mutant is sensitive to expression of the top1-T722A allele; SWAT-GFP and mCherry fusion proteins localize to the cell periphery and vacuole; TDA6 has a paralog, VPS62, that arose from the whole genome duplication | Core | NA | NA | NA |
| 7775-YPR158W | YPR158W | CUR1 | NA | Sorting factor, central regulator of spatial protein quality control; physically and functionally interacts with chaperones to promote sorting and deposition of misfolded proteins into cytosolic compartments; involved in destabilization of [URE3] prions; CUR1 has a paralog, BTN2, that arose from the whole genome duplication | Core | NA | NA | NA |
| 7776-YPR159C-A | YPR159C-A | NA | NA | Protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the cytosol; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching | Accessory | Unknown | S. paradoxus | NA |
| 7777-YPR159W | YPR159W | KRE6 | beta-glucan synthesis-associated protein KRE6|CWH48 | Type II integral membrane protein; required for beta-1,6 glucan biosynthesis; putative beta-glucan synthase; localizes to ER, plasma membrane, sites of polarized growth and secretory vesicles; functionally redundant with Skn1p; KRE6 has a paralog, SKN1, that arose from the whole genome duplication | Core | NA | NA | NA |