Saccharomyces cerevisiae Reference Assembly Panel Database (ScRAPdb)
Saccharomyces cerevisiae Reference Assembly Panel Database (ScRAPdb)
A searchable table of the S. cerevisiae pangenome ORFs defined in Peter et al. (2018) Nature (LINK) is provided below. The listed core/accessory classification and origin assignment are based on the original study. Click on the PanORF ID to find out the detailed presence/absence pattern of the corresponding pangenome ORF in both ScRAPdb and the 1002ScGP strain collections (which were recalculated by ScRAPdb).
| PanORF ID | SGD systematic Name | SGD standard name | Alias | Description | Type | Origin assignment | Mostly likely origin species | NCBI megablast hit |
|---|---|---|---|---|---|---|---|---|
| 7403-YPL054W | YPL054W | LEE1 | NA | Zinc-finger protein of unknown function | Core | NA | NA | NA |
| 7404-YPL055C | YPL055C | LGE1 | NA | Protein of unknown function; null mutant forms abnormally large cells, and homozygous diploid null mutant displays delayed premeiotic DNA synthesis and reduced efficiency of meiotic nuclear division | Core | NA | NA | NA |
| 7405-YPL056C | YPL056C | LCL1 | NA | Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan | Accessory | Ancestral | NA | NA |
| 7406-YPL057C | YPL057C | SUR1 | mannosylinositol phosphorylceramide synthase catalytic subunit SUR1|LPE15|CSG1|BCL21 | Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication | Core | NA | NA | NA |
| 7407-YPL058C | YPL058C | PDR12 | ATP-binding cassette multidrug transporter PDR12 | Plasma membrane ATP-binding cassette (ABC) transporter; weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity | Core | NA | NA | NA |
| 7408-YPL059W | YPL059W | GRX5 | monothiol glutaredoxin GRX5 | Glutathione-dependent oxidoreductase; mitochondrial matrix protein involved at an early step in the biogenesis of iron-sulfur centers along with Bol1p; hydroperoxide and superoxide-radical responsive; monothiol glutaredoxin subfamily member along with Grx3p and Grx4p | Core | NA | NA | NA |
| 7409-YPL060W | YPL060W | MFM1 | LPE10 | Mitochondrial inner membrane magnesium transporter; involved in maintenance of mitochondrial magnesium concentrations and membrane potential; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p | Core | NA | NA | NA |
| 7410-YPL061W | YPL061W | ALD6 | aldehyde dehydrogenase (NADP(+)) ALD6|ALD1 | Cytosolic aldehyde dehydrogenase; activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress | Core | NA | NA | NA |
| 7411-YPL062W | YPL062W | NA | NA | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; YPL062W is not an essential gene; homozygous diploid mutant shows a decrease in glycogen accumulation | Core | NA | NA | NA |
| 7412-YPL063W | YPL063W | TIM50 | protein translocase subunit TIM50 | Essential component of the TIM23 complex; acts as receptor for the translocase of the inner mitochondrial membrane (TIM23) complex guiding incoming precursors from the TOM complex; may control the gating of the Tim23p-Tim17p channel | Core | NA | NA | NA |
| 7413-YPL064C | YPL064C | CWC27 | putative peptidylprolyl isomerase CWC27 | Component of a complex containing Cef1p; putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p; protein abundance increases in response to DNA replication stress | Core | NA | NA | NA |
| 7414-YPL065W | YPL065W | VPS28 | ESCRT-I subunit protein VPS28|VPL13|VPT28 | Component of the ESCRT-I complex; complex is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p; other members include Stp22p, Srn2p, Vps28p, and Mvb12p | Core | NA | NA | NA |
| 7415-YPL066W | YPL066W | RGL1 | NA | Regulator of Rho1p signaling, cofactor of Tus1p; required for the localization of Tus1p during all phases of cytokinesis; green fluorescent protein (GFP)-fusion protein localizes to the bud neck and cytoplasm; null mutant is viable and exhibits growth defect on a non-fermentable (respiratory) carbon source | Core | NA | NA | NA |
| 7416-YPL067C | YPL067C | NA | NA | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL067C is not an essential gene | Core | NA | NA | NA |
| 7417-YPL068C | YPL068C | NA | NA | Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and is induced in response to the DNA-damaging agent MMS | Core | NA | NA | NA |