Saccharomyces cerevisiae Reference Assembly Panel Database (ScRAPdb)
Saccharomyces cerevisiae Reference Assembly Panel Database (ScRAPdb)
A searchable table of the S. cerevisiae pangenome ORFs defined in Peter et al. (2018) Nature (LINK) is provided below. The listed core/accessory classification and origin assignment are based on the original study. Click on the PanORF ID to find out the detailed presence/absence pattern of the corresponding pangenome ORF in both ScRAPdb and the 1002ScGP strain collections (which were recalculated by ScRAPdb).
| PanORF ID | SGD systematic Name | SGD standard name | Alias | Description | Type | Origin assignment | Mostly likely origin species | NCBI megablast hit |
|---|---|---|---|---|---|---|---|---|
| 6518-YNL128W | YNL128W | TEP1 | putative phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase | PTEN homolog with no demonstrated inositol lipid phosphatase activity; plays a role in normal sporulation; homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 and fission yeast ptn1 | Core | NA | NA | NA |
| 6519-YNL129W | YNL129W | NRK1 | ribosylnicotinamide kinase | Nicotinamide riboside kinase; catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis | Core | NA | NA | NA |
| 6520-YNL130C | YNL130C | CPT1 | diacylglycerol cholinephosphotransferase | Cholinephosphotransferase; required for phosphatidylcholine biosynthesis and for inositol-dependent regulation of EPT1 transcription; CPT1 has a paralog, EPT1, that arose from the whole genome duplication | Core | NA | NA | NA |
| 6521-YNL130C-A | YNL130C-A | DGR1 | NA | Protein of unknown function; dgr1 null mutant is resistant to 2-deoxy-D-glucose | Core | NA | NA | NA |
| 6522-YNL131W | YNL131W | TOM22 | MOM22|MAS22|MAS17 | Component of the TOM (Translocase of Outer Membrane) complex; responsible for initial import of mitochondrially directed proteins; mediates interaction between TOM and TIM complexes and acts as a receptor for precursor proteins | Core | NA | NA | NA |
| 6523-YNL132W | YNL132W | KRE33 | ribosome biosynthesis protein KRE33|RRA1 | Protein required for biogenesis of the small ribosomal subunit; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance; essential gene; NAT10, the human homolog, implicated in several types of cancer and premature aging. | Core | NA | NA | NA |
| 6524-YNL133C | YNL133C | FYV6 | NA | Protein of unknown function; required for survival upon exposure to K1 killer toxin; proposed to regulate double-strand break repair via non-homologous end-joining | Core | NA | NA | NA |
| 6525-YNL134C | YNL134C | NA | NA | NADH-dependent aldehyde reductase, involved in detoxification of furfural; expression is up-regulated in the presence of furfural and 5-hydroxymethylfurfural, which are compounds generated during lignocellulosic biomass pre-treatment; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress | Core | NA | NA | NA |
| 6526-YNL135C | YNL135C | FPR1 | peptidylprolyl isomerase FPR1|RBP1|FKB1 | Peptidyl-prolyl cis-trans isomerase (PPIase); binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function; N-terminally propionylated in vivo; mutation is functionally complemented by human FKBP1A | Core | NA | NA | NA |
| 6527-YNL136W | YNL136W | EAF7 | NA | Subunit of the NuA4 histone acetyltransferase complex; NuA4 acetylates the N-terminal tails of histones H4 and H2A | Core | NA | NA | NA |
| 6528-YNL137C | YNL137C | NAM9 | mitochondrial 37S ribosomal protein NAM9|MNA6 | Mitochondrial ribosomal component of the small subunit | Core | NA | NA | NA |
| 6529-YNL138W | YNL138W | SRV2 | adenylate cyclase-binding protein|CAP | CAP (cyclase-associated protein); N-terminus binds adenylate cyclase and facilitates activation by RAS; N-terminus forms novel hexameric star-shaped shuriken structures that directly catalyze cofilin-mediated severing of actin filaments; C-terminus binds and recycles cofilin bound, ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesis; N- and C-termini can function as physically separate proteins; mCAP1 is the mouse homolog | Core | NA | NA | NA |
| 6530-YNL138W-A | YNL138W-A | YSF3 | U2 snRNP complex subunit YSF3|RCP10 | Component of the SF3b subcomplex of the U2 snRNP; essential protein required for splicing and for assembly of SF3b | Core | NA | NA | NA |
| 6531-YNL139C_NumOfGenes_2 | YNL139C | THO2 | RLR1|LDB5|ZRG13 | Subunit of the THO complex; THO is required for efficient transcription elongation and involved in transcriptional elongation-associated recombination; required for LacZ RNA expression from certain plasmids | Core | NA | NA | NA |
| 6532-YNL141W | YNL141W | AAH1 | adenine deaminase | Adenine deaminase (adenine aminohydrolase); converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entry into quiescence via SCF and the proteasome | Core | NA | NA | NA |