A searchable table of the S. cerevisiae pangenome ORFs defined in Peter et al. (2018) Nature (LINK) is provided below. The listed core/accessory classification and origin assignment are based on the original study. Click on the PanORF ID to find out the detailed presence/absence pattern of the corresponding pangenome ORF in both ScRAPdb and the 1002ScGP strain collections (which were recalculated by ScRAPdb).
PanORF ID | SGD systematic Name | SGD standard name | Alias | Description | Type | Origin assignment | Mostly likely origin species | NCBI megablast hit |
---|---|---|---|---|---|---|---|---|
5228-YKL156W_NumOfGenes_2 | YKL156W | RPS27A | eS27|ribosomal 40S subunit protein S27A|S27e|rp61|YS20|S27A | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27A has a paralog, RPS27B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress | Core | NA | NA | NA |
5229-YKL157W | YKL157W | APE2 | metallo-aminopeptidase|YKL158W|LAP1 | Aminopeptidase yscII; may have a role in obtaining leucine from dipeptide substrates; APE2 has a paralog, AAP1, that arose from the whole genome duplication | Core | NA | NA | NA |
5230-YKL159C | YKL159C | RCN1 | NA | Protein involved in calcineurin regulation during calcium signaling; has similarity to H. sapiens DSCR1 which is found in the Down Syndrome candidate region | Core | NA | NA | NA |
5231-YKL160W | YKL160W | ELF1 | NA | Transcription elongation factor with a conserved zinc finger domain; implicated in the maintenance of proper chromatin structure in actively transcribed regions; deletion inhibits Brome mosaic virus (BMV) gene expression | Core | NA | NA | NA |
5232-YKL161C | YKL161C | KDX1 | putative protein kinase KDX1|MLP1 | Protein kinase; implicated in Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p; KDX1 has a paralog, SLT2, that arose from the whole genome duplication | Core | NA | NA | NA |
5233-YKL162C | YKL162C | NA | NA | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion | Core | NA | NA | NA |
5234-YKL162C-A | YKL162C-A | NA | NA | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data | Core | NA | NA | NA |
5235-YKL163W | YKL163W | PIR3 | beta-1,3-glucan linked protein|CCW8 | O-glycosylated covalently-bound cell wall protein; required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway; coding sequence contains length polymorphisms in different strains; PIR3 has a paralog, HSP150, that arose from the whole genome duplication | Accessory | Unknown | S. mikatae | NA |
5236-YKL164C | YKL164C | PIR1 | beta-1,3-glucan linked protein|CCW6 | O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle; PIR1 has a paralog, YJL160C, that arose from the whole genome duplication | Core | NA | NA | NA |
5237-YKL165C | YKL165C | MCD4 | mannose-ethanolamine phosphotransferase MCD4|FSR2|SSU21|ZRG16 | Protein involved in GPI anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes; GPI stands for glycosylphosphatidylinositol | Core | NA | NA | NA |
5238-YKL165C-A | YKL165C-A | NA | NA | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data | Core | NA | NA | NA |
5239-YKL166C | YKL166C | TPK3 | cAMP-dependent protein kinase catalytic subunit TPK3 | cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication | Core | NA | NA | NA |
5240-YKL167C | YKL167C | MRP49 | mitochondrial 54S ribosomal protein MRP49 | Mitochondrial ribosomal protein of the large subunit; not essential for mitochondrial translation | Core | NA | NA | NA |
5241-YKL168C | YKL168C | KKQ8 | putative serine/threonine protein kinase KKQ8 | Putative serine/threonine protein kinase with unknown cellular role; KKQ8 has a paralog, HAL5, that arose from the whole genome duplication | Core | NA | NA | NA |
5242-YKL170W_NumOfGenes_2 | YKL170W | MRPL38 | mitochondrial 54S ribosomal protein YmL38/YmL34|YmL38|YmL34|MRPL34 | Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress | Core | NA | NA | NA |