A searchable table of the S. cerevisiae pangenome ORFs defined in Peter et al. (2018) Nature (LINK) is provided below. The listed core/accessory classification and origin assignment are based on the original study. Click on the PanORF ID to find out the detailed presence/absence pattern of the corresponding pangenome ORF in both ScRAPdb and the 1002ScGP strain collections (which were recalculated by ScRAPdb).
PanORF ID | SGD systematic Name | SGD standard name | Alias | Description | Type | Origin assignment | Mostly likely origin species | NCBI megablast hit |
---|---|---|---|---|---|---|---|---|
5003-YJR097W | YJR097W | JJJ3 | DPH4 | Protein of unknown function; contains a CSL Zn finger and a DnaJ-domain; involved in diphthamide biosynthesis; ortholog human Dph4 | Core | NA | NA | NA |
5004-YJR098C | YJR098C | NA | NA | Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies | Core | NA | NA | NA |
5005-YJR099W | YJR099W | YUH1 | ubiquitin-specific protease YUH1 | Ubiquitin C-terminal hydrolase; cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p | Core | NA | NA | NA |
5006-YJR100C | YJR100C | AIM25 | SLM35 | Mitochondria protein of unknown function; interacts genetically with TOR1 to regulate chronological lifespan, and the response to both heat shock and oxidative stress; involved in maintaining the integrity of the mitochondrial network; negative regulator of mitophagy flux; non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant is viable and displays an elevated frequency of mitochondrial genome loss; similar to murine NOR1 | Core | NA | NA | NA |
5007-YJR101W | YJR101W | RSM26 | mitochondrial 37S ribosomal protein RSM26 | Mitochondrial ribosomal protein of the small subunit | Core | NA | NA | NA |
5008-YJR102C | YJR102C | VPS25 | ESCRT-II subunit protein VPS25|VPL12|VPT25 | Component of the ESCRT-II complex; ESCRT-II is involved in ubiquitin-dependent sorting of proteins into the endosome | Core | NA | NA | NA |
5009-YJR103W | YJR103W | URA8 | CTP synthase URA8 | Minor CTP synthase isozyme (see also URA7); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA8 has a paralog, URA7, that arose from the whole genome duplication | Core | NA | NA | NA |
5010-YJR104C | YJR104C | SOD1 | superoxide dismutase SOD1|CRS4 | Cytosolic copper-zinc superoxide dismutase; detoxifies superoxide; stabilizes Yck1p and Yck2p kinases in glucose to repress respiration; phosphorylated by Dun1p, enters nucleus under oxidative stress to promote transcription of stress response genes; human ortholog SOD1 implicated in ALS complements a null allele; abundance increases under DNA replication stress and during exposure to boric acid; localization to mitochondrial intermembrane space is modulated by MICOS complex | Core | NA | NA | NA |
5011-YJR105W | YJR105W | ADO1 | adenosine kinase | Adenosine kinase; required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle | Core | NA | NA | NA |
5012-YJR106W | YJR106W | ECM27 | NA | Protein involved in calcium homeostasis and exit from quiescence; required for proper trehalose levels during quiescence; may play a role in cell wall biosynthesis, mutants are hypersensitive to antifungal, Papulacandin B; null mutants have increased plasmid loss; interacts with Pdr5p | Core | NA | NA | NA |
5013-YJR107W | YJR107W | LIH1 | putative lipase | Putative lipase | Core | NA | NA | NA |
5014-YJR108W | YJR108W | ABM1 | NA | Protein of unknown function; required for normal microtubule organization | Core | NA | NA | NA |
5015-YJR109C | YJR109C | CPA2 | carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA2 | Large subunit of carbamoyl phosphate synthetase; carbamoyl phosphate synthetase catalyzes a step in the synthesis of citrulline, an arginine precursor | Core | NA | NA | NA |
5016-YJR110W | YJR110W | YMR1 | phosphatidylinositol-3-phosphatase YMR1 | Phosphatidylinositol 3-phosphate (PI3P) phosphatase; involved in various protein sorting pathways, including CVT targeting and endosome to vacuole transport; has similarity to the conserved myotubularin dual specificity phosphatase family | Core | NA | NA | NA |
5017-YJR111C | YJR111C | PXP2 | NA | Peroxisomal matrix protein with naturally active promoter; well-conserved in fungi; localized to peroxisomes under physiological growth conditions; levels of some amino acids are altered upon both knockout and overexpression, suggesting potential involvement of Pxp2p in amino acid metabolism or related cellular metabolic processes (needs further study); GFP-fusion protein displays inherent dual localization with large proportion localizing to cytosol | Core | NA | NA | NA |