ScRAPdb    Saccharomyces cerevisiae Reference Assembly Panel Database (ScRAPdb)



A searchable table of the S. cerevisiae pangenome ORFs defined in Peter et al. (2018) Nature (LINK) is provided below. The listed core/accessory classification and origin assignment are based on the original study. Click on the PanORF ID to find out the detailed presence/absence pattern of the corresponding pangenome ORF in both ScRAPdb and the 1002ScGP strain collections (which were recalculated by ScRAPdb).



PanORF ID                                               SGD systematic Name SGD standard name Alias Description                                               Type Origin assignment Mostly likely origin species NCBI megablast hit
4853-YJL157C YJL157C FAR1 cyclin-dependent protein serine/threonine kinase inhibiting protein FAR1 CDK inhibitor and nuclear anchor; during the cell cycle Far1p sequesters the GEF Cdc24p in the nucleus; phosphorylation by Cdc28p-Cln results in SCFCdc4 complex-mediated ubiquitin-dependent degradation, releasing Cdc24p for export and activation of GTPase Cdc42p; in response to pheromone, phosphorylation of Far1p by MAPK Fus3p results in association with, and inhibition of Cdc28p-Cln, as well as Msn5p mediated nuclear export of Far1p-Cdc24p, targeting Cdc24p to polarity sites Accessory Ancestral NA NA
4854-YJL158C YJL158C CIS3 SCW8|CCW5|PIR4|CCW11 Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family Accessory Unknown S. paradoxus NA
4855-YJL159W_NumOfGenes_2 YJL159W HSP150 heat shock protein HSP150|PIR2|ORE1|CCW7 O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication Accessory Ancestral NA NA
4856-YJL160C YJL160C PIR5 beta-1,3-glucan linked protein Putative protein of unknown function; member of the PIR (Proteins with Internal Repeats) family of cell wall proteins; SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, and mCherry fusion localizes to the vacuole; non-essential gene that is required for sporulation; mRNA is weakly cell cycle regulated, peaking in mitosis; YJL160C has a paralog, PIR1, that arose from the whole genome duplication Core NA NA NA
4857-YJL161W YJL161W FMP33 NA Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Core NA NA NA
4858-YJL162C YJL162C JJJ2 NA Protein of unknown function; contains a J-domain, which is a region with homology to the E. coli DnaJ protein Core NA NA NA
4859-YJL163C YJL163C NA NA Putative protein of unknown function Core NA NA NA
4860-YJL164C YJL164C TPK1 cAMP-dependent protein kinase catalytic subunit TPK1|SRA3|PKA1 cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; phosphorylates and inhibits Whi3p to promote G1/S phase passage; partially redundant with Tpk2p and Tpk3p; phosphorylates pre-Tom40p, which impairs its import into mitochondria under non-respiratory conditions; TPK1 has a paralog, TPK3, that arose from the whole genome duplication Core NA NA NA
4861-YJL165C YJL165C HAL5 protein kinase HAL5 Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication Accessory Ancestral NA NA
4862-YJL166W YJL166W QCR8 ubiquinol--cytochrome-c reductase subunit 8|COR5 Subunit 8 of ubiquinol cytochrome-c reductase (Complex III); Complex III is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p Accessory Ancestral NA NA
4863-YJL167W YJL167W ERG20 bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase|FPP1|FDS1|BOT3 Farnesyl pyrophosphate synthetase; has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis Accessory Ancestral NA NA
4864-YJL168C YJL168C SET2 histone methyltransferase SET2|KMT3|EZL1 Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36 (H3K36), which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain(CTD) of Rpo21p; H3K36me3 (trimethylation) requires Spt6p, proline 38 on H3, CTD of Rpo21p, Ctk1p, and C-terminal SRI domain of Ste2p; relocalizes to the cytosol in response to hypoxia Accessory Ancestral NA NA
4865-YJL169W YJL169W NA NA Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL168C/SET2 Accessory Ancestral NA NA
4866-YJL170C YJL170C ASG7 NA Protein that regulates signaling from G protein beta subunit Ste4p; contributes to relocalization of Ste4p within the cell; specific to a-cells and induced by alpha-factor Accessory Ancestral NA NA
4867-YJL171C YJL171C TOH1 NA GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress Accessory Ancestral NA NA

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