Saccharomyces cerevisiae Reference Assembly Panel Database (ScRAPdb)
Saccharomyces cerevisiae Reference Assembly Panel Database (ScRAPdb)
A searchable table of the S. cerevisiae pangenome ORFs defined in Peter et al. (2018) Nature (LINK) is provided below. The listed core/accessory classification and origin assignment are based on the original study. Click on the PanORF ID to find out the detailed presence/absence pattern of the corresponding pangenome ORF in both ScRAPdb and the 1002ScGP strain collections (which were recalculated by ScRAPdb).
| PanORF ID | SGD systematic Name | SGD standard name | Alias | Description | Type | Origin assignment | Mostly likely origin species | NCBI megablast hit |
|---|---|---|---|---|---|---|---|---|
| 3923-YGR024C | YGR024C | THG1 | tRNA guanylyltransferase | tRNAHis guanylyltransferase; adds a guanosine residue to the 5' end of tRNAH is after transcription and RNase P cleavage; can also catalyze reverse (3'-5') polymerization with certain substrates in a template-dependent reaction; couples nuclear division and migration to cell budding and cytokinesis; essential enzyme conserved among eukaryotes | Core | NA | NA | NA |
| 3924-YGR025W | YGR025W | NA | NA | Putative protein of unknown function; conserved across S. cerevisiae strains | Core | NA | NA | NA |
| 3925-YGR026W | YGR026W | NA | NA | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery | Core | NA | NA | NA |
| 3926-YGR027C_NumOfGenes_2 | YGR027C | RPS25A | eS25|ribosomal 40S subunit protein S25A|S25e|rp45|YS23|S31A|S25A|RPS31A | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S25, no bacterial homolog; RPS25A has a paralog, RPS25B, that arose from the whole genome duplication | Core | NA | NA | NA |
| 3927-YGR028W | YGR028W | MSP1 | YTA4 | Highly-conserved N-terminally anchored AAA-ATPase; distributed in the mitochondrial outer membrane and peroxisomes; involved in mitochondrial protein sorting; functions as an extraction engine in local organelle surveillance to remove and initiate degradation of mistargeted proteins, ensuring fidelity of organelle-specific localization of tail-anchored proteins; contains an N-terminal transmembrane domain and C-terminal cytoplasmic ATPase domain | Core | NA | NA | NA |
| 3928-YGR029W | YGR029W | ERV1 | flavin-linked sulfhydryl oxidase | Flavin-linked sulfhydryl oxidase of the mitochondrial IMS; N-terminus is an intrinsically disordered domain that in the cytosol helps target Erv1p to mitochondria, and in the intermembrane space oxidizes Mia40p as part of a disulfide relay system that promotes intermembrane space retention of imported proteins; functional ortholog of human GFER (ALR); human GFER carrying N-terminal 21 amino acids of Erv1p functionally complements the lethality of the erv1 null mutation | Core | NA | NA | NA |
| 3929-YGR030C | YGR030C | POP6 | ribonuclease P/MRP protein subunit POP6 | Subunit of RNase MRP, nuclear RNase P and telomerase; forms a soluble heterodimer with Pop7p that binds P3 domain of RNase MRP and RNase P RNAs; RNase MRP cleaves pre-rRNA, nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs, while telomerase replenishes telomeric DNA; relocalizes to the cytosol in response to hypoxia | Core | NA | NA | NA |
| 3930-YGR031C-A_NumOfGenes_2 | YGR031C-A | NAG1 | NA | Protein involved in yeast cell wall biogenesis; localizes to the cell periphery; production of Nag1p is dependent upon the presence of Slt2p and Rlm1p; gene is nested within and antisense to IMO32 | Core | NA | NA | NA |
| 3931-YGR032W | YGR032W | GSC2 | 1,3-beta-glucan synthase GSC2|FKS2 | Catalytic subunit of 1,3-beta-glucan synthase; involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; GSC2 has a paralog, FKS1, that arose from the whole genome duplication | Core | NA | NA | NA |
| 3932-YGR033C | YGR033C | TIM21 | FMP17 | Nonessential component of the TIM23 complex; interacts with the Translocase of the Outer Mitochondrial membrane (TOM complex) and with respiratory enzymes; may regulate the Translocase of the Inner Mitochondrial membrane (TIM23 complex) activity | Core | NA | NA | NA |
| 3933-YGR034W_NumOfGenes_2 | YGR034W | RPL26B | uL24|ribosomal 60S subunit protein L26B|L24|YL33|L33B|L26B | Ribosomal 60S subunit protein L26B; binds to 5.8S rRNA; non-essential even when paralog is also deleted; deletion has minimal affections on ribosome biosynthesis; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26B has a paralog, RPL26A, that arose from the whole genome duplication | Core | NA | NA | NA |
| 3934-YGR035C | YGR035C | NA | NA | Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; YGR035C has a paralog, YLR346C, that arose from the whole genome duplication | Core | NA | NA | NA |
| 3935-YGR035W-A | YGR035W-A | NA | NA | Putative protein of unknown function | Core | NA | NA | NA |
| 3936-YGR036C | YGR036C | CAX4 | CWH8 | Dolichyl pyrophosphate (Dol-P-P) phosphatase; has a luminally oriented active site in the ER; cleaves the anhydride linkage in Dol-P-P; required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation | Core | NA | NA | NA |
| 3937-YGR037C_NumOfGenes_2 | YGR037C | ACB1 | long-chain fatty acid transporter ACB1 | Acyl-CoA-binding protein; transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion; protein abundance increases in response to DNA replication stress | Core | NA | NA | NA |